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sars cov 2 omicron ba 1 spike  (Addgene inc)


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    Addgene inc sars cov 2 omicron ba 1 spike
    a Representative images of syncytia formation assay in VeroE6 cells upon treatment (350 µM) with K5 compounds. Scale bar: 50 µm. b Number of nuclei involved in syncytia formation is higher in Wuhan-Hu-1 spike-positive cells than in <t>Omicron</t> <t>BA.1</t> spike-positive cells. c Effect of K5 compounds on syncytia formation induced by Wuhan-Hu-1 spike. d Effect of K5 compounds on syncytia formation induced by Omicron BA.1 spike. Only spike-positive cells were quantified. Data of four (Wuhan-Hu-1) and three (Omicron BA.1) independent experiments. Values are mean ± sd. P values determined by Welch’s t-test: * P < 0.05; ** P < 0.005.
    Sars Cov 2 Omicron Ba 1 Spike, supplied by Addgene inc, used in various techniques. Bioz Stars score: 95/100, based on 106 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/sars+cov+2+omicron+ba+1+spike/SARS-CoV-2+Spike+(S)+Ectodomain+Library+A+(Pooled+library+%23157971)/pmc12789494-318-3-17
    Average 95 stars, based on 106 article reviews
    sars cov 2 omicron ba 1 spike - by Bioz Stars, 2026-09
    95/100 stars

    Images

    1) Product Images from "K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming"

    Article Title: K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming

    Journal: npj Viruses

    doi: 10.1038/s44298-025-00163-4

    a Representative images of syncytia formation assay in VeroE6 cells upon treatment (350 µM) with K5 compounds. Scale bar: 50 µm. b Number of nuclei involved in syncytia formation is higher in Wuhan-Hu-1 spike-positive cells than in Omicron BA.1 spike-positive cells. c Effect of K5 compounds on syncytia formation induced by Wuhan-Hu-1 spike. d Effect of K5 compounds on syncytia formation induced by Omicron BA.1 spike. Only spike-positive cells were quantified. Data of four (Wuhan-Hu-1) and three (Omicron BA.1) independent experiments. Values are mean ± sd. P values determined by Welch’s t-test: * P < 0.05; ** P < 0.005.
    Figure Legend Snippet: a Representative images of syncytia formation assay in VeroE6 cells upon treatment (350 µM) with K5 compounds. Scale bar: 50 µm. b Number of nuclei involved in syncytia formation is higher in Wuhan-Hu-1 spike-positive cells than in Omicron BA.1 spike-positive cells. c Effect of K5 compounds on syncytia formation induced by Wuhan-Hu-1 spike. d Effect of K5 compounds on syncytia formation induced by Omicron BA.1 spike. Only spike-positive cells were quantified. Data of four (Wuhan-Hu-1) and three (Omicron BA.1) independent experiments. Values are mean ± sd. P values determined by Welch’s t-test: * P < 0.05; ** P < 0.005.

    Techniques Used: Tube Formation Assay

    VeroE6 cells or A549 ACE2+ cells were treated with increasing concentrations of heparin, K5, K5OSH, and K5NOSH. a , b The cells remained viable in the presence of heparin and the K5 compounds as evaluated by measuring the ATP levels. VeroE6 or A549 ACE2+ cells were infected with the B.1 c , d or Omicron BA.1 e , f isolates in the presence or the absence of increasing concentrations of heparin, K5, K5OSH, and K5NOSH. Infection was reduced in a concentration-dependent manner as shown by the percentage of plaque reduction compared to SARS-CoV-2 alone. Data are presented as the mean value ± standard error of three independent replicates. * P < 0.05; ** P < 0.005.
    Figure Legend Snippet: VeroE6 cells or A549 ACE2+ cells were treated with increasing concentrations of heparin, K5, K5OSH, and K5NOSH. a , b The cells remained viable in the presence of heparin and the K5 compounds as evaluated by measuring the ATP levels. VeroE6 or A549 ACE2+ cells were infected with the B.1 c , d or Omicron BA.1 e , f isolates in the presence or the absence of increasing concentrations of heparin, K5, K5OSH, and K5NOSH. Infection was reduced in a concentration-dependent manner as shown by the percentage of plaque reduction compared to SARS-CoV-2 alone. Data are presented as the mean value ± standard error of three independent replicates. * P < 0.05; ** P < 0.005.

    Techniques Used: Infection, Concentration Assay

    Related Articles

    Plasmid Preparation:

    Article Title: K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming
    Article Snippet: .. Plasmid encoding for SARS-CoV-2 Omicron BA.1 spike was kindly provided by Prof. Ralf Bartenschlager and purchased from Addgene (#180375). ..

    Article Title: K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming
    Article Snippet: .. Plasmid encoding for SARS-CoV-2 Omicron BA.1 spike was kindly provided by Prof. Dr. Ralf Bartenschlager and purchased from Addgene (#180375). ..



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    a Representative images of syncytia formation assay in VeroE6 cells upon treatment (350 µM) with K5 compounds. Scale bar: 50 µm. b Number of nuclei involved in syncytia formation is higher in Wuhan-Hu-1 spike-positive cells than in <t>Omicron</t> <t>BA.1</t> spike-positive cells. c Effect of K5 compounds on syncytia formation induced by Wuhan-Hu-1 spike. d Effect of K5 compounds on syncytia formation induced by Omicron BA.1 spike. Only spike-positive cells were quantified. Data of four (Wuhan-Hu-1) and three (Omicron BA.1) independent experiments. Values are mean ± sd. P values determined by Welch’s t-test: * P < 0.05; ** P < 0.005.
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    a Representative images of syncytia formation assay in VeroE6 cells upon treatment (350 µM) with K5 compounds. Scale bar: 50 µm. b Number of nuclei involved in syncytia formation is higher in Wuhan-Hu-1 spike-positive cells than in <t>Omicron</t> <t>BA.1</t> spike-positive cells. c Effect of K5 compounds on syncytia formation induced by Wuhan-Hu-1 spike. d Effect of K5 compounds on syncytia formation induced by Omicron BA.1 spike. Only spike-positive cells were quantified. Data of four (Wuhan-Hu-1) and three (Omicron BA.1) independent experiments. Values are mean ± sd. P values determined by Welch’s t-test: * P < 0.05; ** P < 0.005.
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    a Representative images of syncytia formation assay in VeroE6 cells upon treatment (350 µM) with K5 compounds. Scale bar: 50 µm. b Number of nuclei involved in syncytia formation is higher in Wuhan-Hu-1 spike-positive cells than in <t>Omicron</t> <t>BA.1</t> spike-positive cells. c Effect of K5 compounds on syncytia formation induced by Wuhan-Hu-1 spike. d Effect of K5 compounds on syncytia formation induced by Omicron BA.1 spike. Only spike-positive cells were quantified. Data of four (Wuhan-Hu-1) and three (Omicron BA.1) independent experiments. Values are mean ± sd. P values determined by Welch’s t-test: * P < 0.05; ** P < 0.005.
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    Image Search Results


    a Representative images of syncytia formation assay in VeroE6 cells upon treatment (350 µM) with K5 compounds. Scale bar: 50 µm. b Number of nuclei involved in syncytia formation is higher in Wuhan-Hu-1 spike-positive cells than in Omicron BA.1 spike-positive cells. c Effect of K5 compounds on syncytia formation induced by Wuhan-Hu-1 spike. d Effect of K5 compounds on syncytia formation induced by Omicron BA.1 spike. Only spike-positive cells were quantified. Data of four (Wuhan-Hu-1) and three (Omicron BA.1) independent experiments. Values are mean ± sd. P values determined by Welch’s t-test: * P < 0.05; ** P < 0.005.

    Journal: npj Viruses

    Article Title: K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming

    doi: 10.1038/s44298-025-00163-4

    Figure Lengend Snippet: a Representative images of syncytia formation assay in VeroE6 cells upon treatment (350 µM) with K5 compounds. Scale bar: 50 µm. b Number of nuclei involved in syncytia formation is higher in Wuhan-Hu-1 spike-positive cells than in Omicron BA.1 spike-positive cells. c Effect of K5 compounds on syncytia formation induced by Wuhan-Hu-1 spike. d Effect of K5 compounds on syncytia formation induced by Omicron BA.1 spike. Only spike-positive cells were quantified. Data of four (Wuhan-Hu-1) and three (Omicron BA.1) independent experiments. Values are mean ± sd. P values determined by Welch’s t-test: * P < 0.05; ** P < 0.005.

    Article Snippet: Plasmid encoding for SARS-CoV-2 Omicron BA.1 spike was kindly provided by Prof. Ralf Bartenschlager and purchased from Addgene (#180375).

    Techniques: Tube Formation Assay

    VeroE6 cells or A549 ACE2+ cells were treated with increasing concentrations of heparin, K5, K5OSH, and K5NOSH. a , b The cells remained viable in the presence of heparin and the K5 compounds as evaluated by measuring the ATP levels. VeroE6 or A549 ACE2+ cells were infected with the B.1 c , d or Omicron BA.1 e , f isolates in the presence or the absence of increasing concentrations of heparin, K5, K5OSH, and K5NOSH. Infection was reduced in a concentration-dependent manner as shown by the percentage of plaque reduction compared to SARS-CoV-2 alone. Data are presented as the mean value ± standard error of three independent replicates. * P < 0.05; ** P < 0.005.

    Journal: npj Viruses

    Article Title: K5 polysaccharides inhibit SARS-CoV-2 infection by preventing spike-proteolytic priming

    doi: 10.1038/s44298-025-00163-4

    Figure Lengend Snippet: VeroE6 cells or A549 ACE2+ cells were treated with increasing concentrations of heparin, K5, K5OSH, and K5NOSH. a , b The cells remained viable in the presence of heparin and the K5 compounds as evaluated by measuring the ATP levels. VeroE6 or A549 ACE2+ cells were infected with the B.1 c , d or Omicron BA.1 e , f isolates in the presence or the absence of increasing concentrations of heparin, K5, K5OSH, and K5NOSH. Infection was reduced in a concentration-dependent manner as shown by the percentage of plaque reduction compared to SARS-CoV-2 alone. Data are presented as the mean value ± standard error of three independent replicates. * P < 0.05; ** P < 0.005.

    Article Snippet: Plasmid encoding for SARS-CoV-2 Omicron BA.1 spike was kindly provided by Prof. Ralf Bartenschlager and purchased from Addgene (#180375).

    Techniques: Infection, Concentration Assay